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1.
We demonstrate that netrins stimulate proliferation, migration, and tube formation of human endothelial cells in vitro and that this ( ) is independent of known netrin receptors.
2. Suppression of netrin1a messenger RNA in zebrafish inhibits vascular sprouting, implying a ( ) role for netrins during vertebrate development. We also show that netrins accelerate ( ) in an in vivo model of ischemia and that they reverse neuropathy and vasculopathy in a diabetic murine
model.
3.
2を簡潔にまとめると、Netrins promote ( ) and ( ) angiogenesis.
＜回答＞
1. stimulation
2. 2a proangiogenic 2b
neovascularization
3. 3a. developmental または
Netrins promote developmental
3b. therapeutic または
therapeutic angiogenesis
Netrins Promote Developmental and Therapeutic Angiogenesis
Brent D. et al. ( Science 4 August 2006; pp. 640 - 644 )
Axonal guidance and vascular patterning share several guidance cues, including proteins in the netrin family. We demonstrate that netrins stimulate proliferation, migration, and tube formation of human endothelial cells in vitro and that this stimulation is independent of known netrin receptors. Suppression of netrin1a messenger RNA in zebrafish inhibits vascular sprouting, implying a proangiogenic role for netrins during vertebrate development. We also show that netrins accelerate neovascularization in an in vivo model of ischemia and that they reverse neuropathy and vasculopathy in a diabetic murine model. We propose that the attractive vascular and neural guidance functions of netrins offer a unique therapeutic potential.
1. Aminoglycoside and fluoroquinolone antibiotics, as well as mitomycin C, a DNA-damaging agent, induced transformation in Streptococcus pneumoniae. This ( ) required an intact competence regulatory cascade.
2. In response to antibiotic stress, S. pneumoniae, which lacks an SOS-like system, exhibited genetic transformation. The design of antibiotherapy should take into consideration this ( ) of a major human pathogen to increase its rate of genetic exchange in response to antibiotics
3.
下線部を簡潔に言い換えると、genetic ( ) of a major human pathogen.
＜回答＞
1. induction
2. potential
3.
transformability
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